The aerial parts of Cassia auriculata were weighed accurately and defatted With petroleum ether. The defatted mare was then refluxed with 70% ethanol for about 5-6 hrs. The 70% ethanolic (Flavonoid rich fraction) extract of the plant of Cassia auriculata was then subjected for the evaluation of antimicrobial activity and for the estimation of Total Flavonoid Contents. 70° 0 ethanolic (flavonoid rich fraction) extract of the plant of Cassia auriculata were subjected for the determination of antifungal and antibacterial activities.
From all the studies, it was found that the Flavonoid rich fractions showed potent antidandruff and antibacterial activities. It was also observed that 70° 0 Ethanolic (flavonoid rich fraction) of the plant showed maximum antimicrobial activity. The isolated phytoconstituents were encorporated into gel and shampoo. All the prepared formulations were subjected to the various evaluation parameters such as colour, pH, spreadability, drug content, drug diffusion etc.
Antimicrobial activity of the llavonoid rich fraction of the plant was evaluated by detecting the zone of inhibition with respect to desired microorganisms. Skin irritation test on animals was done and stability study of the formulation was performed as per lCH guidelines. The flavonoid rich fractions have shown a significant antimicrobial activity with special emphasis on M. furfur.
The antidandruff activity of the flavonoid rich fraction of Cassia auriculata was reported as a first time. The antifungal and antibacterial activities were attributed to the rich amount of flavonoid present in the 70% alcoholic extract of Cassia auriculata. The flavonoid rich fraction was formulated into a gel and shampoo preparation. The drug released (flavonoids) was studies with the help of franz diffusion cell with the help of Qurecetin as standard.
Antimicrobial activity of the llavonoid rich fraction of the plant was evaluated by detecting the zone of inhibition with respect to desired microorganisms. Skin irritation test on animals was done and stability study of the formulation was performed as per lCH guidelines. The flavonoid rich fractions have shown a significant antimicrobial activity with special emphasis on M. furfur.
The antidandruff activity of the flavonoid rich fraction of Cassia auriculata was reported as a first time. The antifungal and antibacterial activities were attributed to the rich amount of flavonoid present in the 70% alcoholic extract of Cassia auriculata. The flavonoid rich fraction was formulated into a gel and shampoo preparation. The drug released (flavonoids) was studies with the help of franz diffusion cell with the help of Qurecetin as standard.
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