ANTI INFLAMMATORY PROPERTIES OF ENTADA ABYSSINICA

Entada abyssinica Steud. ex A. Rich (Mimosaceae). is a tree that is found all over tropical Africa. The plant has been used for the treatment of bronchitis, coughs and to alleviate arthritic pains. The defatted methanolic extract of Entada abyssinica was evaluated for anti-inflammatory activity in acute and chronic models of inilannnation. The extract (50-200 mg/kg, p.o) exhibited dose-dependent and significant inhibition of the carrageenan-induced rat paw oedema in rats.

The extract (50-200 mg/kg, p.o) was also found to inhibit the acetic acid-induced vascular permeability in a dose-dependent fashion in mice using indomethacin as standard. A statistically significant inhibition of the carrageenan-induced paw oedema in rats was observed following oral administration of E. abyssinica leaf methanolic extract at 3 h. Oedema was inhibited by 32.3, 47.5 and 49.1% by 50, 100 and 200 MG/kg of extract. The plant reduced the degree of peritoneal increased vascular permeability produced by acetic acid in mice, the dye leakage being significantly reduced by 28.1 , 45.3 and 55.50 0 at oral doses of 50, 100 and 200 mg/kg. The methanolic extract of Entada abyssinica showed the significant anti-inflammatory activity as compare to standard drug indomethacin.

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GRANULATION PROCESS

GRANULATION PROCESS: Granulation process :- It is a process in which the powder particles are made to adhere to form larger, multi particle entities called granules. A dough mass is prepared to form the granules.

CINNAMON AS ANTI MICROBIAL AGENT

Hands are primary mode of transmission of microbes and infections. Through hand hygiene a simple and least expensive means of prevent health care associated infections specially derived from environmental surfaces. The present research was aimed to evaluate the antimicrobial efficacy of Cinnamon oil extract found that it showed better antimicrobial activity. Also the research was carried out to formulate and evaluate the Hand wash gel containing Cinnamon oil. The anti-microbial activity of the formulated hand wash gel was tested against Escherichia coli, Staphylococcus aureus, Bacilius subtilis and pseudomonas vulagaris by spread plate techniques and the results obtained were compared with standard antibiotic.

WONDER DRUG FAKE OR REALITY ?

1938: Di-ethyl stilbestrol (DES) was created. DES was the first synthetic estrogen ever synthesized; it was cheap to produce, more potent than natural estrogen, and could be taken orally. In the rush to make and market DES, Eli Lilly became one ofthe drug's major manufacturers. In America alone there were 267 drug companies that made and distributed DES and other similar synthetic estrogen because it was un-patented and easily produced.No controlled studies were ever conducted by the drug companies to determine the effectiveness or safety of DES for use during pregnancy, even after some scientists started questioning its efficacy in the 19505. As early as 1953, research revealed that DES did not work that DES actually brought about higher rates of premature birth and infant mortality yet DES continued to be prescribed to pregnant women for decades.

PHARMA AND YOUR HEALTH

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